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Cytokines stimulate CD44 expression and release in ECs. A: IL-1β and TNF-α enhance CD44 expression in ECs. ECs were incubated with or without IL-1β/TNF-α, IFN-γ, and CD40L. Cell lysates were analyzed for CD44 expression. Bars represent mean ± SEM from four different donors. B: Proinflammatory cytokines stimulate CD44 release from growth-arrested ECs. CD40L and IL-1β/TNF-α induce sCD44 release in ECs. Bars represent mean ± SEM.
