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Soluble CD44 stimulates IL-1β expression and release from ECs. Growth-arrested ECs from three different donors were stimulated with sCD44 (80 ng/ml) in the presence or absence of a CD44H antibody. Soluble CD44 induces IL-1β protein in ECs (A) as well as IL-1β mRNA (B). This effect is abolished by the addition of an anti-CD44H antibody or by heat-inactivation of the sCD44-containing medium. Anti-IgG2A (negative control) does not affect IL-1β protein levels.
