Table 1.
Histopathological Findings in Liver
| Histopathological findings* | Breeding term Group† | Experiment 1
|
Experiment 2
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 12W
|
26W
|
36W
|
|||||||||
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 1 | 2 | 3 | ||
| No. of animals examined | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| Centrilobular hepatocellular hypertrophy | + | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2+ | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Hepatocellular altered foci | 5‡ | 5§ | 5¶ | 0 | 5∥ | 5** | 0 | 5∥ | 5** | 1†† | |
| Hepatocellular adenoma | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 0 | |
| Hepatocellular carcinoma | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4 | 1 | 0 | |
*
Grading: +−, slight; +, mild; 2+, moderate; 3+, severe.
†
Experiment 1: 1, NDEN + clofibrate; 2, NDEN + Wy-14,643; 3, NDEN alone; 4, no treatment. Experiment 2: 1, NDEN + clofibrate; 2, NDEN alone; 3, no treatment.
‡
Predominantly clear cell foci, and small number of amphophilic cell foci.
§
Amphophilic cell foci and clear cell foci.
¶
Predominantly clear cell foci and small number of amphophilic cell foci (basophilic).
∥
Clear and acidophilic cell foci and amphophilic cell foci.
**
Predominantly clear and acidophilic cell foci, and small number of amphophilic cell foci (basophilic).
††
Clear cell foci.