Figure 1.

Kinetics of death of tg7, tgNSE, and tgGFAP mice after intraocular (i.o.), intracerebral (i.c.), intraperitoneal (i.p.), and oral inoculation of hamster scrapie strain 263K. The doses used for each type of inoculation are described in the Materials and Methods. The data are represented as percentage of animals dead versus days after infection, which were pooled from at least two independent experiments (tg7 mice: n = 6 intraocular, n = 15 intracranial, n = 13 intraperitoneal, and n = 19 oral; tgNSE mice: n = 5 intraocular, n = 10 intracranial, n = 10 intraperitoneal, and n = 12 oral; tgGFAP mice: n = 6 intraocular, n = 8 intracranial, n = 12 intraperitoneal, and n = 6 oral). The results of the intracranial inoculation were similar to what was published previously.20–22