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The amyloid-lowering effect of indomethacin requires p65/RelA. The ratio of Aβ42/40 in conditioned media of indomethacin-treated (25 to 100 μmol/L) control NHI3T3 fibroblasts, and fibroblasts genetically deficient for p65/RelA. The experiment was repeated three times, and a representative experiment is shown. Results are mean ± SEM, n = 3 per group; *, P < 0.05.
