Table 1.

Effects of Indomethacin and Nimesulide on Total Brain Cortex Levels of PGE₂, TxB₂, and Urinary Levels of 2,3-dinor-TxB₂ and 2,3-dinor-6-ketoPGF_1α

	Placebo (n = 10)	Indomethacin (n = 10)	Nimesulide (n = 10)
PGE2 (percentage)	100	36 ± 3†	85 ± 4
TxB2 (percentage)	100	13 ± 1†	105 ± 5
2,3-Dinor-TxB2 (ng/mg creatinine)	58 ± 10	4.5 ± 1.1†	56 ± 9.1
2,3-Dinor-6ketoPGF1α (ng/mg creatinine)	0.55 ± 0.08	0.38 ± 0.09*	0.12 ± 0.05‡

Tg2576 mice received the drugs in the drinking water starting at 8 month of age until they were 15-month old. 

Results are expressed as means ± SEM. 

^*P = 0.03; 

^†P < 0.01; 

^‡P < 0.001.