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. 2004 Dec;165(6):1883–1894. doi: 10.1016/s0002-9440(10)63241-5

Figure 1.

Figure 1

Chronic myocarditis and fibrosis is increased in IFN-γ-deficient mice. Mice deficient in IL-12Rβ1 (IL12R−/−) or IFN-γ (IFNg−/−) were compared to wild-type BALB/c control mice for the level of myocarditis and fibrosis in the heart 35 days after CB3 infection. Mice received 103 PFU of CB3 or PBS intraperitoneally on day 0 and hearts were collected on day 35 after infection. Myocarditis or fibrosis were not observed in the heart at day 35 of age-matched uninfected, mock PBS-treated BALB/c, IL-12Rβ1-deficient, or IFN-γ-deficient mice, or in BALB/c mice inoculated with uninfected heart homogenates. Myocarditis was assessed as the percentage of the heart with inflammation and necrosis compared to the overall size of the heart section. Fibrosis was assessed as the percentage of the heart section with collagen deposition, which stains bright blue with Masson’s trichrome stain. Data show one representative experiment of five conducted with 7 to 10 mice per group. Data are presented as the mean ± SEM. *, P < 0.05; ***, P < 0.001.