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. 2004 Dec;165(6):1883–1894. doi: 10.1016/s0002-9440(10)63241-5

Figure 2.

Figure 2

Increased fibrosis is associated with areas of inflammation in the heart. Uninfected, mock-treated BALB/c (A), IL-12Rβ1-deficient, or IFN-γ-deficient mice did not develop cardiac fibrosis. Mice deficient in IL-12Rβ1 (C) or IFN-γ (D) were compared to wild-type BALB/c (B) mice for the level of fibrosis and inflammation in the heart 35 days after CB3 infection. Mice received 103 PFU of CB3 or PBS intraperitoneally on day 0 and hearts were collected on day 35 after infection. Fibrosis was assessed as the area of the heart section with collagen deposition, which stains bright blue with Masson’s trichrome stain. Individual experiments were conducted five times with 7 to 10 mice per group, with one representative heart shown for each group. Original magnifications, ×64.