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. 2004 Dec;165(6):2135–2145. doi: 10.1016/S0002-9440(10)63263-4

Figure 4.

Figure 4

Ultrastructure of wild-type and ElasCCK2 exocrine pancreas. A–F: Electron photomicrographs of ultrathin epoxy resin sections through exocrine pancreas of wild-type (A, B) and ElasCCK2 mice (C–F). A: A typical acinar cell with basally located nucleus, endoplasmic reticulum (arrowheads), mitochondria (arrows), and zymogen granules is shown. B: Numerous adherens junctions and desmosomes (arrows and arrowheads) are found between neighbor acinar cells in the wild-type animals. Both types of junctions are missing at the cell-cell contacts between neighbor acinar cells in ElasCCK2 exocrine pancreas (arrows in D) and increased gaps between the cells observed (asterisks). C: Note dilatations of the endoplasmic reticulum (asterisks) and organelles fusing with mitochondria (arrows) in ElasCCK2 exocrine pancreas. E: In acinar cells of ElasCCK2 pancreas commonly autophagocytic bodies (arrows) and big gap (asterisks) are observed. F: Note enhanced fibrosis (arrowheads) and detachment of basal membrane (arrow) from acini in ElasCCK2 mice. Scale bars: 1.2 μm (A, C); 0.6 μm (B, E); 0.3 μm (D, F).