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. 2004 Dec;165(6):2033–2043. doi: 10.1016/s0002-9440(10)63254-3

Figure 1.

Figure 1

AGE-caused renal dysfunction and histological changes. Rats were treated with AGE-RSA for 6 weeks and then sacrificed for evaluation of AGE decomposition in serum and renal tissue (A), total urinary volume (B), and urinary protein (C). AGE-induced ultrastructural changes in the kidney of control (D), RSA-treated (E), AGE-RSA-treated (F), and AGE-AG-treated (G) rats were examined by electron microscope. RSA, rat serum albumin; AGE-RSA, glycated RSA; AGE-AG, co-administration of AG with AGE-RSA. *, P < 0.05 versus control; #, P < 0.05 versus AGE-RSA.