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. 2004 Dec;165(6):2123–2133. doi: 10.1016/s0002-9440(10)63262-2

Figure 6.

Figure 6

Inducible nitric oxide synthase (NOS-2) generation is inhibited in L. donovani-infected mice deficient in TNF and LTα. A–C: NOS-2-stained liver sections from C57BL/6 (A), B6.TNF−/− (B), and B6.LTα−/− (C) mice taken at day 14 after infection. Arrows in insets indicate NOS-2-positive staining. Note the strong staining in granulomas found in C57BL/6 mice. D: The number of NOS-2 mRNA molecules per 1000 HPRT molecules found in the livers of C57BL/6, B6.TNF−/−, and B6.LTα−/− mice, as indicated. #, Indicates where the data for naïve mice is shown (all levels were below 2 NOS-2 mRNA per 1000 HPRT mRNA molecules). Statistically differences of P < 0.05 (asterisk), relative to NOS-2 mRNA levels in C57BL/6 mice are indicated. Original magnifications: ×100; ×400 insets (A–C).