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Efficacies and cytotoxicities of PMPA and related ANPs against VV and CV in HFF
| Compound | GS no.a | CC50 (μM) | VV
|
CV
|
||
|---|---|---|---|---|---|---|
| EC50 (μM) | SIb | EC50 (μM) | SIb | |||
| PMPA | GS 1278 | >300 | >300 | — | >300 | — |
| Bis[(isopropoxycarbonyl)oxymethyl]PMPA | GS 4331 | >157.4 | >157.4 | — | >157.4 | — |
| (Isopropyl-l-alaninyl)phenyl PMPA | GS 7340 | >143 | 23.5 | >6.1 | 98.9 | >1.4 |
GS, Gilead Sciences.
SI = CC50/EC50.
