TABLE 4.
Activities of ANPs against VV in HFF
| Compound | GS no.a | EC50 (μM) for VV strain:
|
||
|---|---|---|---|---|
| Copenhagen | WR | NYC | ||
| HPMPC (CDV) | GS 0504 | 33 | 32 | 36 |
| cHPMPC | GS 0930 | 38 | 46 | 16 |
| (S)-HPMPA | GS 0577 | 3.5 | 7.6 | 5.9 |
| 2-(Butyloxycarbonyl)phenyl-cHPMPC | GS 3857 | 32 | 11 | 24 |
| (Phenethyl l-alaninyl)cHPMPC (mixed diastereomers) | GS 7356 | 7.1 | 15 | 16 |
| (Ethyl-l-alaninyl)cHPMPC (isomer I) | GS 7357 | 15 | 27 | 27 |
| (Ethyl-l-alaninyl)cHPMPC (isomer II) | GS 7358 | 15 | 31 | 28 |
| Bis[(pivaloyl)oxymethyl]PMEA | GS 0840 | 5.1 | 18.5 | 23 |
| Bis(butyl-l-alaninyl)PMEA | GS 8357 | 4.4 | 4.4 | 5.1 |
| PMEDAP | GS 0573 | 204 | 128 | 122 |
| PME-N6-(cyclopropyl)DAP | GS 8369 | 23 | 18 | 12 |
| Bis(butyl-l-alaninyl)PME-N6-(cyclopropyl)DAP | GS 8361 | 0.08 | 0.12 | 0.14 |
| PME-N6-(trifluoroethyl)DAP | GS 8367 | 42 | 38 | 50 |
| PME-N6-(dimethyl)DAP | GS 8368 | 35 | 22 | 34 |
| PME-N6-(2-propenyl)DAP | GS 8370 | 25 | 23 | 16 |
a
GS, Gilead Sciences.