Different fingerprinting profiles obtained by digesting the tet(M) amplicons from 64 tet(M)-positive pneumococci with four endonucleases. Lane M, molecular size marker (100-bp ladder). Lane A, undigested tet(M) amplicon. Lanes 1a to 1e, different AciI profiles (AciI1 to AciI5). Lanes 2a and 2b, different RsaI profiles (RsaI1 and RsaI2). Lane 3, MseI profile. Lane 4, TaqI profile.