TABLE 1.

Macrolide resistance and resistance genotypes of 4,281 pneumococcal strains documented by nationwide studies in Germany, 1992 to 2002^a

Study	Age group	Disease	Study period	No. of centers	No. of strains	No. (%) of strains				Reference
						Eryr	mef(A) positiveb	erm (B) positiveb	mef (A) and erm (B) negativeb
A	Children	IPD	1997-2000	123	690	122 (17.7)	85 (69.7)	35 (28.7)	2 (1.6)	von Kries et al. (25)c
B	Adults and children	IPD	1992-2000	86	3,186	226 (7.1)	117 (51.8)	107 (47.3)	2 (0.9)	Reinert et al. (17)
C	Adults	IPD, RTI	2001-2002	35	405	51 (12.6)	24 (47.1)	26 (51.0)	1 (2.0)	Felmingham et al. (5)
Total					4,281	399 (9.3)	226 (56.6)	168 (46.6)	5 (1.3)

^aAbbreviations: RTI, respiratory tract infections; IPD, invasive pneumococcal disease; Ery^r, erythromycin resistant.

^bThe denominator was the number of macrolide-resistant strains.

^cUpdated data.