TABLE 2.

Patient demographic data and MICs for seven macrolide-resistant strains isolated in Germany, 1992 to 2000^a

Strains	Yr of isolation	German town	Age	Source	Macrolide resistance:		MIC (μg/ml)
					GT	PT	ERY	ROX	AZM	CLA	CLI	JOS	SPI	TEL	Q-D	PEN	CTX	LEV	TET	SXT
NRZ 288	1998	Chemnitz	5 yr	Blood	erm(B)−, mef(A)−	cMLSB	≥32	≥32	≥32	≥32	8	16	≥32	0.25	1	0.016	0.016	1	0.5	0.06/1.2
NRZ 796	2000	Kassel	3 mo	Blood	erm(B)−, mef(A)−	iMLSB	8	8	8	4	0.25	8	8	0.03	1	0.016	0.016	0.5	0.5	0.06/1.2
PS 2938	1999	Dillingen (Saar)	36 yr	Pleural puncture	erm(B)−, mef(A)−	cMLSB	≥32	≥32	≥32	≥32	≥32	≥32	≥32	0.06	1	0.25	0.06	2	32	0.25/4.75
PS 2909	1999	Munich	33 yr	BAL	erm(B)−, mef(A)−	M	16	16	32	16	0.06	4	8	0.06	1	8	4	1	32	0.25/4.75
PW 555	2000	Weingarten	28 yr	CSF	erm(B)−, mef(A)−	iMLSB	2	4	4	2	0.125	1	2	0.03	1	0.016	0.016	1	0.5	0.25/4.75
NRZ 462	1999	Heidelberg	8 yr	CSF	erm(B)+, mef(A)−	iMLSB	≥32	≥32	≥32	≥32	0.5	≥32	≥32	0.125	1	0.016	0.016	0.5	32	0.5/9.5
NRZ 810	2000	Frankfurt	5 yr	CSF	erm(B)−, mef(A)+	cMLSB	≥32	≥32	≥32	≥32	≥32	≥32	≥32	0.25	1	1	1	0.5	32	1/19

^aAbbreviations: GT, genotype; PT, phenotype; erm(B)−, erm(B) negative; erm(B)+, erm(B) positive; mef(A)−, mef(A) negative; mef(A)+, mef(A) positive; M phenotype, macrolide resistance; ERY, erythromycin A; ROX, roxithromycin; AZM, azithromycin; CLA, clarithromycin; CLI, clindamycin; JOS, josamycin; SPI, spiramycin; TEL, telithromycin; Q-D, quinupristin-dalfopristin; PEN, penicillin G; CTX, cefotaxime; LEV, levofloxacin; TET, tetracycline; SXT, sulfamethoxazole-trimethoprim; BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid.