Fig. 4.

Comparison of chromosomal DNA, gene expression, and protein profiles between first- and high-generation tumors. (a) Array CGH showing the relative chromosome copy numbers of the parent biopsy, first- and high-generation tumors. (b) Bar graph presenting the genes with the biggest difference in expression levels between the first- and high-generation tumors. (c) Immunoblot analysis of protein extracts from first- and high-generation tumor tissue. VEGF was analyzed from cerebrospinal fluid. (d) Signaling pathways differentially activated in the two tumor phenotypes.