Table 2.
SNP | -1131T>C | S19W | ||||||||
TT | TC | CC | Carrier* Frequency (95% CIs) | Less common allele Frequency (95% CIs) | SS | SW | WW | Carrier* Frequency (95% CIs) | Less common allele Frequency (95% CIs) | |
Pune Indians (n = 524) | 336 | 170 | 18 | 0.36 (0.32–0.40) | 0.20 (0.17–0.22) | 497 | 27 | 0 | 0.05 (0.03–0.07) | 0.03 (0.02–0.04) |
UK whites (n = 237) | 218 | 19 | 0 | 0.08 (0.05–0.11) | 0.04 (0.02–0.06) | 210 | 26 | 1 | 0.11 (0.07–0.15) | 0.06 (0.04–0.08) |
P value | <0.00001 | 0.0015 |
Asian Indians (adults from the Pune Children Study) and UK white subjects (adults from the Plymouth EarlyBird study).
P values are calculated for differences in genotype frequencies between Pune Indians and UK white subjects. *Carrier frequency indicates individuals carrying at least one copy of the less common allele at either polymorphism. Neither population showed any deviation from HWE for either polymorphism (p > 0.05).