Table 3.
Association of serum triglyceride concentrations and other lipid parameters (mg/dl) with APOA5 genotype for -1131T>C and S19W.
| -1131T>C | S19W | |||||||||
| TT | CT | CC | Effect on lipid (SD)* | P Value | SS | SW+WW | Effect on lipid (SD) | P Value | ||
| Triglycerides | Pune Indians | 91.5 (3.1) | 110.1 (4.3) | 106.0 (13.1) | 0.25 (0.12, 0.39) | 0.0003 | 97.2 (2.5) | 114.0 (11.0) | 0.25 (-0.11, 0.60) | 0.17 |
| UK whites | 95.3 (3.8) | 125.3 (12.6) | - | 0.50 (0.11, 0.89) | 0.01 | 94.4 (3.7) | 123.0 (12.1) | 0.41 (0.10, 0.73) | 0.008 | |
| HDL | Pune Indians | 41.4 (0.7) | 41.2 (0.9) | 37.2 (2.9) | -0.03 (-0.21, 0.15) | 0.73 | 41.1 (0.6) | 41.7 (2.4) | 0.07 (-0.32, 0.47) | 0.71 |
| UK whites | 55.8 (0.95) | 54.2 (2.3) | - | -0.03 (-0.49, 0.44) | 0.91 | 56.1 (0.96) | 51.9 (2.5) | -0.33 (-0.72, 0.07) | 0.10 | |
| LDL | Pune Indians | 96.8 (1.8) | 101.6 (2.5) | 100.1 (7.6) | 0.11 (-0.08, 0.29) | 0.25 | 98.2 (1.5) | 103.5 (6.3) | 0.16 (-0.24, 0.56) | 0.44 |
| UK whites | 115.5 (2.4) | 123.9 (5.5) | - | 0.26 (-0.21, 0.73) | 0.27 | 115.5 (2.3) | 121.1 (8.3) | 0.05 (-0.35, 0.46) | 0.79 | |
| Total Cholesterol | Pune Indians | 156.6 (2.0) | 164.6 (2.7) | 158.6 (8.5) | 0.19 (0.01, 0.36) | 0.04 | 158.8 (1.6) | 167.9 (7.1) | 0.25 (-0.15, 0.64) | 0.22 |
| UK whites | 189.8 (2.5) | 202.6 (5.4) | - | 0.36 (-0.11, 0.83) | 0.13 | 190.0 (2.5) | 197.1 (8.6) | 0.13 (-0.27–0.53) | 0.52 | |
Values are given as mean (SE), units (mg/dl); P values are based on linear regression analysis. SD = standard deviations. *Effect on triglycerides in Pune Indians is for CC+CT individuals versus TT individuals and for both studies are based on logged values. There are no -1131CC individuals in the UK white population.