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. Author manuscript; available in PMC: 2007 Jul 1.
Published in final edited form as: Epilepsy Res. 2006 Mar 20;70(1):3–14. doi: 10.1016/j.eplepsyres.2006.02.002

Figure 1.

Figure 1

Kynurenic acid withdrawal-induced seizure elicits time-dependent cell death. a) Withdrawal of kynurenic acid from cultures chronically treated with kynurenic acid and Mg2+ results in seizure-like activity. b) Increasing seizure duration increases the amount of LDH released from neurons. Note seizure duration greater that 5 min results in maximal cell death. Media samples were taken 24 hours following seizure for LDH assay. c) Seizure induced cell death is reduced by the NMDA antagonist MK801 (10 μM) and the AMPA antagonist CNQX (20 μM). Cells were incubated with drug during 40 min seizure period. Data shown are mean ± sem (n= 5), * denotes P<0.01 vs. effect of seizure (post hoc Dunnet's test).