FIG. 10.

Cartoon depicting the possible roles of membrane glycoconjugates and JAM1 in reovirus entry into Peyer's patches. Our data suggest that binding of type 1 reoviruses to NeuAcα2-3Gal-containing glycoconjugates on M cell apical surfaces (a) results in uptake (b) and transcytosis to the basolateral side of the epithelium (c). This provides access to JAM1 on basolateral membranes (d), which would mediate infection of adjacent epithelial cells (e). M cells can also be infected (6), but whether infection occurs following uptake from the apical surface (i and ii) or basolateral surface (not shown) remains to be determined.