TABLE 4.
Quantification of FCV-neutralizing antibodies after FCV challenge
| Cat | Vector | Neutralizing antibody titer at daya
|
|||||
|---|---|---|---|---|---|---|---|
| Prechallenge | Postchallenge
|
||||||
| 6 | 3 | 6 | 8 | 10 | 14 | ||
| 1 | pCF-7 | − | − | − | 125 | 1,000 | 6,000 |
| 2 | pCF-7 | − | − | 10 | 50 | 250 | 1,250 |
| 3 | pCF-7 | − | − | − | − | 125 | 2,000 |
| 4 | pCF-ΔU3 | − | − | − | − | 20 | 20 |
| 5 | pCF-ΔU3 | − | − | − | − | 10 | 100 |
| 6 | pCF-ΔU3 | − | − | − | − | 20 | 150 |
| 7 | pCF-FCV24 | − | − | − | 10 | 20 | 250 |
| 8 | pCF-FCV24 | − | − | − | 10 | 20 | 500 |
| 9 | pCF-FCV24 | − | − | − | − | 10 | 250 |
| 10 | pCF-FCV24 | − | − | − | − | 20 | 30 |
| 11 | pCF-FCV24 | − | − | − | − | − | 20 |
| 12 | pCF-FCV24 | − | − | − | 10 | 30 | 300 |
| 13 | pCF-FCV24-U3 | − | − | − | − | 20 | 100 |
| 14 | pCF-FCV24-U3 | − | − | − | 200 | 1,000 | 10,000 |
| 15 | pCF-FCV24-U3 | − | − | − | − | − | 20 |
| 16 | pCF-FCV24-U3 | − | − | − | 10 | 50 | 30 |
| 17 | pCF-FCV24-U3 | − | − | − | 10 | 1,000 | 2,000 |
| 18 | pCF-FCV24-U3 | − | − | − | − | − | 100 |
a
FCV-neutralizing antibodies were detected as described in Materials and Methods. Titers are expressed as maximum dilutions that neutralize FCV under the conditions used. FCV-neutralizing antibody titers below 10 were scored as negative (−).