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. 2003 Jul;77(14):8031–8038. doi: 10.1128/JVI.77.14.8031-8038.2003

TABLE 2.

Pathogenicity of chimeric HA viruses in micea

Virus Mean virus titer ± SD
Mean change in body wt (%) ± SD
% dead (no. dead/8 tested)
Nasal turbinates Lungs Day 5 Day 14
Wild type
    A/WSN-R 5.0 ± 0.3 8.2 ± 0.1 −27.4 ± 1.1 NAb 100 (8)
    B/Lee-R 4.7 ± 0.1 5.6 ± 0.1 −19.3 ± 7.9 (−11.7) 87.5 (7)
Chimeric
    ANSBH 4.0 ± 0.3 2.8 ± 0.3 2.6 ± 1.0 4.6 ± 1.2 0 (0)
    ANTBH 5.3 ± 0.3 4.9 ± 0.1 −17.3 ± 0.7 −8.3 ± 0.4 0 (0)
    ANSTBH 5.3 ± 0.4 4.6 ± 0.1 −20.9 ± 0.3 −6.2 ± 8.8 0 (0)
Control (PBS) NA NA 2.9 ± 1.3 7.1 ± 0.2 0 (0)
a

Mice were intranasally inoculated with virus (105 TCID50) and monitored for 14 days. Virus titers were determined as log10 TCID50/g at 3 days postinoculation and reported as means ± standard deviation (n = 3). Changes in body weight are reported as means ± standard deviations (n = 3). The data in parentheses are from one mouse. Control mice were mock inoculated with phosphate-buffered saline (PBS).

b

NA, not applicable.

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