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The synthetic peptide is specific for Zta and can disrupt all three natural variants. The ability of ZEDpep or of an unrelated coiled coil control peptide, SKIP1 (IAALERKNAALEQKAIAALEYKIAALEKK [13]), to disrupt the ability of each of the three Zta full-length proteins to interact with AP1 sites was evaluated with EMSA. The DNA binding relative to the no-peptide control value is indicated. The error bars represent the standard deviation from two independent experiments.
