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Sequence alignment of mammalian CRs and trout CR/20β-HSDs at the N terminus. Three Gly residues of the Rossmann fold (GXXXGXG) are boxed. The predicted α-helix and β-sheet are displayed by α and β, respectively. The α-sheet on the bottom line corresponds to the position in trout CR/20β-HSD type B. ratiCR, rat inducible carbonyl reductase; ratnCR, rat noninducible carbonyl reductase.
