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Lethal dose values for isogenic strains in a neonatal rat sepsis model of infection
| Strain | LD50a
|
|
|---|---|---|
| Expt 1 | Expt 2 | |
| A909 (wild type) | 2.1 × 105 | 3.9 × 105 |
| AJ200 (A909ΔrpoE) | 2.1 × 107 | 1.6 × 107 |
| AJ8D3 (A909 Tn917::rpoE) | 1.3 × 107 | 1.7 × 106 |
LD50 were calculated by the method of Reed and Muench (29). Each strain was tested on five pups per group.
