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The OspA vaccine fails to stimulate NO production in macrophages from TLR2−/− C3H/HeJ mice. Bone marrow macrophages from wild-type (WT) and TLR2−/− C3H/HeJ mice were incubated with 100 ng of LPS per ml or the indicated concentrations of OspA, detergent-free OspA, unlipidated OspA, or sonicated B. burgdorferi. Supernatants were collected at 24 h and assayed for nitrate production by the Greiss reaction. Values are means ± standard deviations for triplicate samples.
