TABLE 2.
Effectiveness of OspA vaccination in TLR2−/− C3H/HeJ mice after challenge with B. burgdorferi infection
| Genotype | Immunizationa | No. infected/totalb |
|---|---|---|
| C3H/HeJ | PBS | 6/8 |
| C3H/HeJ | OspA | 4/17 |
| TLR2−/− C3H/HeJ | PBS | 8/8 |
| TLR2−/− C3H/HeJ | OspA | 2/17 |
a
Mice were immunized by subcutaneous injection of 2.5 μg of OspA diluted in PBS. Control mice were immunized with equal amounts of detergent present in OspA vaccine diluted in PBS.
b
Infection was determined by PCR detection of B. burgdorferi recA DNA in rear ankle joints, hearts, and ears collected 2 to 4 weeks postchallenge.