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Capacity of S. aureus strain BB255 and its isogenic mutants to be internalized by osteoblasts. The isogenic strains BB255 (rsbU), GP268 (BB255 rsbU+), IK181 (BB255 ΔrsbUVWsigB), and MB138 (BB255 rsbW) were cocultured with osteoblasts at a multiplicity of infection of 100:1. The figure shows the results from one representative experiment of at least three, and the data are the means and standard deviations of three replicate cultures.
