TABLE 3.
Effects of combinations of methicillin and defensins on survival of S. aureus strains
| Strain | FIC indexa
|
Bactercidal activity (ratio)b
|
||
|---|---|---|---|---|
| hBD3 | CAP18 | hBD3 | CAP18 | |
| MRSA-1 | 0.45 | 0.45 | 1.2 | 1.2 |
| MRSA-4 | 0.26 | 0.84 | 8.8 | 1.3 |
| MRSA-8 | 0.16 | 0.45 | 4.8 | 2.1 |
| MRSA-9 | 0.11 | 0.09 | 1.8 | 1.3 |
| MRSA-10 | 0.26 | 0.26 | 1.1 | 1.6 |
| MRSA-11 | 0.09 | 0.16 | 1.2 | 1.1 |
| MRSA-12 | 0.19 | 0.19 | 2.7 | 8.0 |
| MRSA-13 | 0.22 | 0.15 | 1.5 | 2.6 |
| MRSA-14 | 0.32 | 0.32 | 15.4 | 1.7 |
| MRSA-22 | 0.15 | 0.12 | 1.1 | 1.6 |
a
The FIC index was calculated as described in Materials and Methods.
b
The ratio of bactericidal activity was determined as follows: bactericidal activity for methicillin-treated cells/bactericidal activity for nontreated cells.