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. 2006 Nov 1;20(21):2996–3009. doi: 10.1101/gad.1483906

Figure 4.

Figure 4.

Gene expression induced by LRP130 in primary hepatocytes. Transcription of genes responsive to PGC-1α coactivation and implicated in gluconeogenesis, mitochondrial respiration, and fatty acid oxidation were measured using RT quantitative PCR. (A) Forced expression of LRP130 in primary hepatocytes. Statistical comparisons are made between GFP and LRP130. (B) Effect of forced expression of LRP130 in primary knockout (KO) hepatocytes. Residual PGC-1α transcript was detected in the knockout animals using primers for exon 2 (ex2). (C) Coforced expression of LRP130 and PGC-1α in primary hepatocytes. Statistical comparisons are made between GFP coexpressed with PGC-1α and LRP130 coexpressed with PGC-1α. Experiments were performed in triplicate and are representative of n = 3 independent biological experiments. (*) p < 0.05; (**) p < 0.01; (***) p < 0.001. Error bars represent standard deviation.