TABLE 1.

BALF and serum TNF-α levels after intratracheal LPS administration^a

Mice	Treatment	No. of mice	Fold increase in TNF-α in:
			BALF	Serum
WT	PBS	3	1	1
	LPS	5	22.2b	1.29
Elafin	PBS	3	0.85	0.45b
	LPS	7	39.1b	0.07b,c

^aBALF and sera from elafin mice and WT mice were obtained 24 h after intratracheal administration of PBS or LPS, and TNF-α levels were measured by ELISA (see Materials and Methods). Nonparametric data were expressed as fold increases compared with the values for WT mice that received PBS (median). Statistical significance was assessed by using the Kruskal-Wallis and Mann-Whitney tests.

^bSignificantly different from the value obtained for WT mice that received PBS (P < 0.05).

^cSignificantly different from the value obtained for WT mice that received LPS (P < 0.05).