TABLE 1.
CSF inflammatory responses in mice challenged with heat-inactivated pneumococcia
| Mice | Concn of cytokines in CSF (pg/ml)
|
Concn of WBC in CSF (106 cells/ml) | |||||
|---|---|---|---|---|---|---|---|
| TNF-α | IL-6 (103) | Gamma interferon | Monocyte chemotactic protein 1 (103) | IL-10 | IL-12p70 | ||
| WT | 1,121 ± 351 | 45.2 ± 20.0 | 19.2 ± 8.5 | 33.8 ± 28.3 | 903 ± 1,282 | 106 ± 35.4 | 17.5 ± 10.9 |
| gp91−/− | 741 ± 504 | 26.6 ± 10.4 | 16.3 ± 2.8 | 9.8 ± 9.8 | 782 ± 416 | 92.7 ± 57.5 | 23.6 ± 14.5 |
| p47−/− | 469 ± 379b | 16.0 ± 14.0b | 17.6 ± 3.7 | 12.4 ± 9.6 | 827 ± 720 | 115 ± 49.5 | 6.0 ± 2.3c |
a
The data were obtained by a cytometric bead array analysis. The values are means ± standard deviations for eight WT animals, seven gp91−/− animals, and three p47−/− animals. All parameters were significantly elevated in WT animals challenged with heat-inactivated R6 pneumococci compared to the values obtained for saline-treated controls (P < 0.05, as determined by a Mann-Whitney U test).
b
Significantly different (P < 0.01) than the value obtained for WT animals.
c
Significantly different (P < 0.05) than the value obtained for WT animals as determined by an unpaired t test.