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. 2003 Jul;71(7):3837–3843. doi: 10.1128/IAI.71.7.3837-3843.2003

FIG. 4.

FIG. 4.

Secretion of IL-12 (p40) and IL-10 by DCs is stimulated by recombinant HpaA and Omp18. Blood DCs (maximum 88.6% ppDC, maximum 6.76% pmDCs) were incubated with rHpaA or rOmp18 (1 μg/ml) for 24 h in RPMI-10% FCS. (A) IL-10 secretion from human DCs as determined by ELISA. No secretion of IL-10 was observed under basal conditions (n = 3). (B) IL-12 (p40) concentrations were also determined in the cell culture supernatant by ELISA. Both proteins showed a statistically significant stimulation of IL-10 or IL-12 release (n = 5). Mean values I standard error of the mean are shown. **P < 0.01, as determined by one-way analysis of variance.