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The positive inotropic effect of troglitazone is not mediated via Ca2+ handling in the sarcoplasmic reticulum. Pretreatment with thapsigargin or ryanodine did not inhibit the inotropic effect of troglitazone (bolus injection of 1 μmol, n=5, respectively). Changes of parameters are expressed as per cent changes from the baseline values. *P<0.05 vs vehicle.
