Table II. Combining rsc or swi/snf mutations with nhp6a nhp6b mutations causes increased sickness or lethality.
| rsc allele | nhp6allele | Growthat 28°C | NPTa(°C) | Strainb |
|---|---|---|---|---|
| WT | NHP6A/B | +++ | >38 | YBC605 |
| WT | nhp6ΔΔ | ++ | 38 | YBC1304/1305/1307 |
| arp9-1 | NHP6A/B | +++ | 35 | YBC1536 |
| arp9-1 | nhp6ΔΔ | + | 33 | YBC1526 |
| arp9ΔC | NHP6A/B | ++ | 35 | YBC775 |
| arp9ΔC | nhp6ΔΔ | – | 28 | YBC1525 |
| sth1-2 (P646L) | NHP6A/B | +++ | >38 | YBC946 |
| sth1-2 (P646L) | nhp6ΔΔ | ++ | 35 | YBC1520 |
| sth1-3 (S806L,T881M) | NHP6A/B | +++ | >38 | YBC944 |
| sth1-3 (S806L,T881M) | nhp6ΔΔ | + | 35 | YBC1517 |
| rsc9-1 | NHP6A/B | ++ | 33 | YBC1158 |
| rsc9-1 | nhp6ΔΔ | + | 33 | YBC1621 |
| swi/snf allele | ||||
| snf2Δ | NHP6A/B | +++ | >38 | YBC27 |
| snf2Δ | nhp6ΔΔ | ++ | 35 | YBC1514 |
aNPT; non-permissive temperature.
bAll strains are derivatives of the S288C genetic background.
+++, WT growth; ++, slow growth; +, very slow growth; –, no growth.