Table 2.
Absolute reductions* (mmol/l) (with 95% confidence intervals) and percentage reductions† in serum LDL cholesterol concentration according to statin and daily dose (summary estimates from 164 randomised placebo controlled trials)
|
Daily dose (mg)
|
|||||
|---|---|---|---|---|---|
| Statin | 5 | 10 | 20 | 40 | 80 |
| Atorvastatin | 1.51 (1.28 to 1.74), 31% | 1.79 (1.62 to 1.97), 37% | 2.07 (1.90 to 2.25), 43% | 2.36 (2.12 to 2.59), 49% | 2.64 (2.31 to 2.96), 55% |
| Fluvastatin | 0.46 (0.18 to 0.75), 10% | 0.74 (0.55 to 0.93), 15% | 1.02 (0.90 to 1.13), 21% | 1.30 (1.19 to 1.41), 27% | 1.58 (1.40 to 1.76), 33% |
| Lovastatin | — | 1.02 (0.71 to 1.34), 21% | 1.40 (1.21 to 1.59), 29% | 1.77 (1.60 to 1.94), 37% | 2.15 (1.86 to 2.43), 45% |
| Pravastatin | 0.73 (0.54 to 0.92), 15% | 0.95 (0.83 to 1.07), 20% | 1.17 (1.10 to 1.23), 24% | 1.38 (1.31 to 1.46), 29% | 1.60 (1.46 to 1.74), 33% |
| Rosuvastatin | 1.84 (1.74 to 1.94), 38% | 2.08 (1.98 to 2.18), 43% | 2.32 (2.20 to 2.44), 48% | 2.56 (2.42 to 2.70), 53% | 2.80 (2.63 to 2.97), 58% |
| Simvastatin | 1.08 (0.93 to 1.22), 23% | 1.31 (1.22 to 1.40), 27% | 1.54 (1.46 to 1.63), 32% | 1.78 (1.66 to 1.90), 37% | 2.01 (1.83 to 2.19), 42% |
*
Absolute reductions are standardised to usual serum LDL cholesterol concentration of 4.8 mmol/l before treatment (mean concentration in trials).
†
Percentage reductions are independent of pretreatment LDL cholesterol concentration; 95% confidence intervals on percentage reductions can be derived by dividing those on absolute reductions by 4.8.