Table 4.

Reduction (%) in risk of ischaemic heart disease events (relative odds reduction) in 49 randomised trials^* according to number of years in trial at time of event and reduction in LDL cholesterol concentration

	LDL cholesterol reduction (mmol/l)			P value (test for trend)
Year in trial	0.2-0.7*	0.8-1.4†	≥1.5‡
1st and 2nd§	6	19	33	0.015
3rd, 4th, and 5th	19	31	50	<0.001
6th and subsequent	21	30	52	0.026

^*21 trials, mean reduction 0.5 mmol/l.

^†24 trials, mean reduction 1.0 mmol/l.

^‡5 trials, mean reduction 1.6 mmol/l.

^§Excludes 8 trials that lasted less than one year.