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. 2003 Jun 28;326(7404):1423. doi: 10.1136/bmj.326.7404.1423

Table 7.

Expected % decrease in incidence of ischaemic heart disease events for specified decreases in serum cholesterol according to age at event, based on 10 largest cohort studies of serum cholesterol and ischaemic heart disease6

LDL cholesterol reduction (mmol/l)*
Age (years) 0.6 1.0 1.4 1.8 2.2 2.6 3.0
50 39 56 68 77 84 88 91
60 27 41 52 61 68 74 79
70 20 31 41 49 56 62 67
*

Decreases in incidence follow from linear dose-response relation indicating constant proportional change in risk for specified change in cholesterol. Thus at age 60 years relative risk for decrease of 1.0 mmol/l is 0.59 (41% decrease), therefore 0.591.4 = 0.48 (52% decrease) for 1.4 mmol/l decrease.