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. 2006 Oct 2;103(41):15172–15177. doi: 10.1073/pnas.0607053103

Fig. 1.

Fig. 1.

Plasma clearance of P- and NP-GUS (A) or AP- and NP-GUS (B) in MR−/− and MR+/+ mice. (A) P- (□) and NP-GUS (■) were infused at a dose of 0.2 mg/kg and plasma GUS levels measured over the next hour. Note that the NP-GUS in the MR+/+ mice was very rapidly cleared (AUC = 411 units/h per ml) in contrast to the much slower clearance in MR−/− mice (AUC = 4,703 units/h per ml). P-GUS is also rapidly cleared in the MR+/+ mice (AUC = 473 units/h per ml) but shows an intermediate rate of clearance in MR−/− mice (AUC = 1,524 units/h per ml), reflecting the M6P-mediated clearance in the absence of MR. (B) Clearance rates of AP-GUS (▴) (AUC = 4,395 units/h per ml) and NP-GUS (■) (AUC = 4,703 units/h per ml) appear nearly equivalent in MR−/− mice.