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. 2006 Sep 27;103(41):15190–15195. doi: 10.1073/pnas.0604890103

Fig. 6.

Fig. 6.

Proposed model for viral mRNA export in HVS. These data led to the findings that ORF57 trafficking through the nucleolus is essential for viral mRNA nuclear export. WT ORF57 is able to traffic through the nucleolus, bind intronless viral mRNAs, and associate with cellular mRNA export proteins to achieve viral mRNA nuclear export (i). However, ORF57 mutants incapable of nucleolar trafficking are unable to export bound viral mRNA, even though assembly of the export complex appears to be unperturbed (ii).