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. 2006 Sep 27;103(41):15218–15223. doi: 10.1073/pnas.0607131103

Fig. 2.

Fig. 2.

Chelatable Zn2+ is required for the induction of spike timing-dependent LTP in cortical input to the LA. (A Upper) Cortico-amygdala EPSPs recorded before (trace 1) and after (trace 2) LTP induction. (A Lower) AP-EPSP pairing-induced LTP (arrow) of the EPSP in the LA neuron in the same experiment as in Upper. (B) Summary graph of the LTP experiments as in A (n = 9). (C) Bath application of TPEN (100 nM) prevents LTP. Traces in Upper show EPSPs recorded before (trace 1) and after (trace 2) the pairing procedure. The trace in the middle demonstrates AP-EPSP pairing. (D) Summary graph of the LTP experiments as in C (n = 6). (E) Blockade of GABAARs (100 μM PTX) rescues LTP in the presence of TPEN. Traces are EPSPs recorded before (trace 1) and after (trace 2) LTP induction. (F) Summary graph of the LTP experiments as in E (n = 5). Error bars indicate SEM.