Fig. 5.

Deletion mutants of GB virus C NS5A inhibit HIV replication in Jurkat cells. Schematic representation of the full-length NS5A from the IFN-S GBV-C isolate, and key deletion mutants from IFN-R isolate NS5A are shown. Numbering represents the NS5A amino acids included in the expression clone. HIV replication (measured by p24 antigen release into culture supernatant) in each cell line on days 0, 4, 5, 6, and 7 is shown. NS5A proteins that inhibited HIV replication compared with the VC expressing GFP are shaded.