Fig. 1.
Topographic mapping of the CST is disrupted in EphA4−/− mice. To investigate whether fore- and hindlimb CST axons behaved differently in EphA4−/− mice compared with control mice, they were separately labeled with the anterograde tracer BDA. The percentage of fore- and hindlimb axons that branched into the gray matter of the cord was measured in mutant and control mice. Significantly more hindlimb axons branched into the gray matter in EphA4−/− mice compared with control mice. ∗, P < 0.01.