Table 1.

Sets of protease and RT mutations used as input features for predicting drug susceptibility

Mutation set	Description	Mutations
Complete	Mutations occurring ≥ 2 times in the data set	PIs: 225 mutations at 70 positions. NRTIs: 371 mutations at 132 positions.
Expert panel	IAS-USA mutation panel (9). The complete list of mutations for each drug class is shown here. The subset of mutations associated with each drug in the primary publication was used for prediction.	PIs: 10F/I/R/V; 16E; 20M/R/I; 24I; 30N; 32I; 33F/I/V; 36I/L/V; 46I/L; 47V/A; 48V; 50V/L; 53L; 54V/M/L/A/T/S; 60E; 62V; 63P; 71V/T/I/L; 73S/A/C/T; 74P; 77I; 82A/F/T/S; 84V; 85V; 88D/S; 90M; 93L NRTIs: 41L; 44D; 62V; 65R; 67N; 69ins; 70R; 74V; 75I; 77L; 115F; 116Y; 118I; 151M; 184V/I; 210W; 215Y/F; 219Q/E NNRTIs: 100I; 103N; 106M/A; 108I; 181C/I; 188L/C/H; 190S/A; 225H; 230L; 236L
Nonpolymorphic TSMs	Nonpolymorphic mutations significantly more common in treated compared with untreated persons (10)	PIs: 10F/R; 11I; 20I/T/V; 23I; 24I; 30N; 32I; 33F; 34Q; 35G; 43T; 46I/L/V; 47A/V; 48M/V; 50L/V; 53L/Y; 54A/L/M/S/T/V; 55R; 58E; 66F; 67F; 71I; 73A/C/S/T; 74A/P/S; 76V; 79A; 82A/F/S/T; 84A/C/V; 85V; 88D/S/T; 89V; 90M; 92R; 95F NRTIs: 41L; 43E/N/Q; 44A/D; 62V; 65R; 67E/G/N; 69D/N/S/ins; 70R; 74I/V; 75I/M/T; 77L; 98G; 115F; 116Y; 151M; 184I/V; 203K; 208Y; 210W; 215F/I/V/Y; 218E; 219E/N/Q/R; 223Q; 228H/R NNRTIs: 100I; 101E/N/P; 103N/S; 106A/M; 108I; 138Q; 181C/I/V; 188C/H/L; 190A/E/Q/S; 221Y; 225H; 227L; 230L; 236L; 238T

IAS-USA, International AIDS Society–USA.