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The signal gain of the signal-on E-DNA sensor is relatively large. Shown are the sensor responses using alternating current voltammetry to different concentrations of fully complementary target DNA (3) (Left) and mismatched DNA (4) in 10 mM phosphate buffer including 0.1 M NaCl (pH 7.3). Twenty nanomolar mismatched DNA only shows <5% signal change (Right).
