The reproductive success of inbred (solid bars) and outbred (open bars) mice. (A) Males in enclosures. Inbred males had significantly lower reproductive success than outbred males (total offspring, n = 1028, χ2 = 87.7, P < 0.0001; weaned offspring, n = 476, χ2 = 60.8, P < 0.0001). (B) Males in laboratory. The reproductive success of inbred males was significantly lower than outbred males (total offspring, n = 606, χ2 = 10.35, P < 0.005; weaned offspring, n = 526, χ2 = 11.9, P < 0.001). (C) Females in enclosures. Inbred females had significantly lower reproductive success than outbred females (total offspring, n = 2074, χ2 = 4.7, P < 0.05; weaned offspring, n = 956, χ2 = 7.3, P < 0.01). (D) Females in laboratory. The reproductive success of inbred females was significantly lower than outbred females (total offspring, n = 606, χ2 = 6.9, P < 0.01; weaned offspring, n = 526, χ2 = 16, P < 0.001) (****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05).