Table 2.
Lupus-associated autoantibodies in the serum of TALL-1 transgenic mice
| Autoantibodies | Age (mo) | TALL-1 tg (n) | Non-tg littermates (n) | P value |
|---|---|---|---|---|
| Antinuclear (IgG)* | 2–3 | 7‡(9) | 1§ (8) | |
| 5–6 | 9 (9) | 1§ (8) | ||
| 8–9 | 8 (8) | 1§ (6) | ||
| Anti-dsDNA (IgG)† | <2 | 697 ± 284 (7) | 277 ± 67 (7) | NS |
| 3–4 | 842 ± 351 (7) | 235 ± 49 (7) | <0.005 | |
| 6–7 | 2,515 ± 428 (5) | 970 ± 344 (7) | <0.019 | |
| 8–10 | 12,293 ± 6,767 (11) | 1,070 ± 602 (12) | <0.017 | |
| Anti-dsDNA (IgM)† | <2 | 275 ± 33 (7) | 46 ± 5 (7) | <0.001 |
| 3–4 | 1,684 ± 920 (7) | 63 ± 13 (7) | <0.003 | |
| 6–7 | 6,998 ± 5,515 (5) | 98 ± 14 (7) | <0.001 | |
| 8–10 | 13,712 ± 9,147 (11) | 79 ± 14 (12) | <0.001 | |
| Anti-histone (Ig)† | <2 | 741 ± 264 (7) | 52 ± 8 (7) | <0.001 |
| 3–4 | 837 ± 436 (7) | 53 ± 14 (7) | <0.003 | |
| 6–7 | 4,220 ± 933 (5) | 60 ± 10 (7) | <0.001 | |
| 8–10 | 16,553 ± 4,618 (11) | 295 ± 173 (12) | <0.001 |
*
Data is shown as number of ANA-positive (mean ± 2 SD of transgene negative littermates) mice using ANA screen kit.
† Data is represented as mean ± SE for each group. Values are shown as units/ml.
‡ Includes two weak positives.
§Weak positive.