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. 2006 Aug 30;1:24. doi: 10.1186/1745-6150-1-24

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Copyright © 2006 Reason and Zhou; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Clonal lineage analysis of selected Fab families showing implied relationships based on shared mutations. A) Clustal guide tree generated from an alignment of all clonally related VH3-15 H chains isolated from donor 003 PPS 6B-specific Fabs. Fabs marked with an asterisk (*) all have a 2 codon insertion in the VH CDR2 region. B) Clustal guide tree generated from an alignment of all clonally related V1-4 lambda L chains isolated from donor 023 PPS 6B-specific Fabs. Fab marked with an asterisk (*) has a 1 codon insertion in the L chain FR2 region. C) Clustal guide tree generated from an alignment of all clonally related B3 kappa L chains isolated from donor 010 PPS 6B-specific Fabs. Fab marked with an asterisk (*) has a 6 codon deletion in the L chain CDR1 region.