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. Author manuscript; available in PMC: 2007 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265–5269. doi: 10.1016/j.bmcl.2006.08.004

Scheme 2.

Scheme 2

(i) Pd/C, H2, EtOAc; (ii) a) (BrCH2CO)2O DMF, rt, 1 h; b) NaN3, DMF, rt, 24 h (93% yield from 7a); (iii) 1-acetylimidazole, DMF, 24 h (quantitative); (iv) CuI, L-ascorbate, DIPEA, CH3CN/tBuOH/H2O, rt (73% yield); (v) TFA-HS(CH2)2SH-H2O, rt, 1 h (76% yield).